Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline
نویسندگان
چکیده
منابع مشابه
Development of spontaneous recurrent seizures after kainate-induced status epilepticus.
Acquired epilepsy (i.e., after an insult to the brain) is often considered to be a progressive disorder, and the nature of this hypothetical progression remains controversial. Antiepileptic drug treatment necessarily confounds analyses of progressive changes in human patients with acquired epilepsy. Here, we describe experiments testing the hypothesis that development of acquired epilepsy begin...
متن کاملDipeptidyl peptidase-4 inhibitor ameliorates status epilepticus seizures and cognitive disturbances in a rat model of temporal lobe epilepsy
Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of tempora...
متن کاملTreatment of acute seizures and status epilepticus.
Overt status epilepticus and persistent obtundation after a witnessed clinical seizure are neurologic emergencies. Early recognition and intervention in the electroclinical syndrome of status epilepticus reduces morbidity, although treatment of the underlying etiology is also critical. This review outlines key concepts related to status epilepticus, delineates an approach to the early managemen...
متن کاملMicroRNAs in the pathophysiology and treatment of status epilepticus
MicroRNA (miRNA) are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output. Prolonged seizures (status epilepticus, SE) can cause damage to brain regions such as the hippocampus and result in cognitive deficits and the pathogenesis of epilepsy. Emerging work in animal models has found that SE...
متن کاملClinical Profile of Status epilepticus (SE) in Children in a Tertiary Care Hospital in Bihar.
BACKGROUND Status epilepticus (SE) is a common, life threatening neurologic disorder that is essentially an acute, prolonged epileptic crisis. SE can represent an exacerbation of a pre-existing seizure disorder, the initial manifestation of a seizure disorder, or an insult other than a seizure disorder. OBJECTIVES To study the aetiology, clinical profile, and outcome of SE in pediatric age gr...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2017
ISSN: 0013-9580
DOI: 10.1111/epi.13645